HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 53628936, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 4(3H)-Pyrimidinone, 2-chloro-3-methyl-6-(4-pyridinyl)- | HCID 11276081 | — |
| Reactant | tert-Butyl 2-(4-chlorophenyl)piperazine-1-carboxylate | HCID 44558599 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 53628936 | HCID 53628936 | 94.3% |
Reaction Steps
A solution of 4-(tert-butoxycarbonyl)-3-(4-chlorophenyl)piperazine (330 mg, 1.1 mmol), 2-chloro-3-methyl-6-(4-pyridyl)pyrimidin-4-one (246 mg, 1.1 mmol) and triethylamine (170 μl, 1.22 mmol) in tetrahydrofuran were refluxed. Usual workup and purification by silica gel column chromatography gave 2-(1-(tert-butoxy-carbonyl)-2-(4-chlorophenyl)-piperazine-4-yl)-3-methyl-6-(4-pyridyl)pyrimidin-4-one (500 mg, 93%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07504411B2 |
| Source dataset | uspto-grants-2009_03 |
| ORD ID | ord-de30e35dd9cd4166848baa3186d42cd8 |
| Source note | uspto-grants-2009_03 |