反应详情

Dimethyl sulfoxide (60 ml) solution of 4-chlorophenacylbromide (11.11 g, 65.9 mmol) and water (1.7 ml) were stirred. The solution was extracted with ethyl acetate 3 times and washed with water twice and brine and then dried over sodium sulfate. After removal of the solvent, the residue was washed with hexane-ethyl acetate and dried to give 4-chlorophenylglyoxal (4.43 g, 50%).

1. extractionThe solution was extracted with ethyl acetate 3 times
2. washwashed with water twice
3. dry with materialbrine and then dried over sodium sulfate
4. customAfter removal of the solvent
5. washthe residue was washed with hexane-ethyl acetate
6. customdried