2-Amino-5-nitropyridine → 2-Cyclopropyl-3-methyl-6-nitroimidazo[1,2-a]pyridine

Participants

Reaction Steps

Operations similar to Production Example 1-(1) were conducted using 1-cyclopropyl-1-propanone, and successively those of Production 1-(2) were conducted using 2-amino-5-nitropyridine. The solid whereupon obtained was suspended in ethyl acetate, washed with saturated aqueous sodium hydrogencarbonate solution and purified by silica gel column chromatography (hexane/ethyl acetate=4/1) to provide the title compounds as yellow crystals.

Provenance & Evidence