4-Bromo-2-fluorobenzoic acid → 3-Fluoro-4'-(trifluoromethyl)-[1,1'-biphenyl]-4-carboxylic acid

HRID 1784737Notes

Reaction equation

HRID 1784737 reaction equation
[F:1][C:2]([F:13])([F:12])[C:3]1[CH:8]=[CH:7][C:6](B(O)O)=[CH:5][CH:4]=1.Br[C:15]1[CH:20]=[CH:19][C:18]([C:21]([OH:23])=[O:22])=[C:17]([F:24])[CH:16]=1>>[F:24][C:17]1[CH:16]=[C:15]([C:6]2[CH:7]=[CH:8][C:3]([C:2]([F:13])([F:12])[F:1])=[CH:4][CH:5]=2)[CH:20]=[CH:19][C:18]=1[C:21]([OH:23])=[O:22]

Participants

3

Reactant 2

HCID 3026814-Bromo-2-fluorobenzoic acidHCID 27343894-(Trifluoromethyl)phenylboronic acid

Product 1

HCID 231205273-Fluoro-4'-(trifluoromethyl)-[1,1'-biphenyl]-4-carboxylic acid

Procedure

Production Example 14 was repeated except that 4-(trifluoromethyl)phenylboronic acid and 4-bromo-2-fluorobenzenecarboxylic acid were used, to provide the title compound as white solid.

Sources & evidence

ORD record
ord-c01d2bd09a234c93973e07e594693927
Source dataset
uspto-grants-2009_03
Patent number
US07504412B2

Reaction notes

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