4-Benzyloxy-1-[2-(4-hydroxymethyl-phenyl)-2-oxo-ethyl]-1H-pyridin-2-one → 4-(5-Bromo-pyridin-2-ylmethoxy)-1-{2-oxo-2-[2-(2,2,2-trifluoro-acetyl)-1,2,3,4-tetrahydro-isoquinolin-7-yl]-ethyl}-1H-pyridin-2-one

HRID 178474Notes

Reaction equation

HRID 178474 reaction equation
[Br:27][c:28]1[cH:29][cH:30][c:31]([CH2:34][O:35][c:36]2[cH:37][c:38](=[O:42])[nH:39][cH:40][cH:41]2)[n:32][cH:33]1.[CH2:1]([O:2][c:3]1[cH:4][cH:5][n:6]([CH2:7][C:8]([c:9]2[cH:10][cH:11][c:12]([CH2:13][OH:14])[cH:15][cH:16]2)=[O:17])[c:18](=[O:19])[cH:20]1)[c:21]1[cH:22][cH:23][cH:24][cH:25][cH:26]1.[Cl:43][CH2:44][C:45](=[O:46])[c:47]1[cH:48][cH:49][c:50]2[c:55]([cH:56]1)[CH2:54][N:53]([C:57]([C:58]([F:59])([F:60])[F:61])=[O:62])[CH2:52][CH2:51]2>>[Br:27][c:28]1[cH:29][cH:30][c:31]([CH2:34][O:35][c:36]2[cH:37][c:38](=[O:42])[n:39]([CH2:44][C:45](=[O:46])[c:47]3[cH:48][cH:49][c:50]4[c:55]([cH:56]3)[CH2:54][N:53]([C:57]([C:58]([F:59])([F:60])[F:61])=[O:62])[CH2:52][CH2:51]4)[cH:40][cH:41]2)[n:32][cH:33]1

Participants

4

Reactant 3

HCID 670068424-Benzyloxy-1-[2-(4-hydroxymethyl-phenyl)-2-oxo-ethyl]-1H-pyridin-2-oneHCID 670074364-(5-bromo-pyridin-2-ylmethoxy)-1H-pyridin-2-oneHCID 866236881-[7-(2-chloro-acetyl)-3,4-dihydro-1H-isoquinolin-2-yl]-2,2,2-trifluoro-ethanone

Product 1

HCID 866236934-(5-Bromo-pyridin-2-ylmethoxy)-1-{2-oxo-2-[2-(2,2,2-trifluoro-acetyl)-1,2,3,4-tetrahydro-isoquinolin-7-yl]-ethyl}-1H-pyridin-2-one

Sources & evidence

ORD record
ord-4d023fee4a4d42229370143081b94780
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

Loading…