4-Methoxycarbonylphenylboronic acid → Methyl 4-(5-methoxy-2-pyridyl)benzoate

HRID 1784741Notes

Reaction equation

HRID 1784741 reaction equation
[CH3:1][O:2][C:3]([C:5]1[CH:10]=[CH:9][C:8](B(O)O)=[CH:7][CH:6]=1)=[O:4].Br[C:15]1[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][N:16]=1>>[CH3:22][O:21][C:18]1[CH:19]=[CH:20][C:15]([C:8]2[CH:9]=[CH:10][C:5]([C:3]([O:2][CH3:1])=[O:4])=[CH:6][CH:7]=2)=[N:16][CH:17]=1

Participants

3

Reactant 2

HCID 27343694-Methoxycarbonylphenylboronic acidHCID 111481512-Bromo-5-methoxypyridine

Product 1

HCID 23120538Methyl 4-(5-methoxy-2-pyridyl)benzoate

Procedure

Repeating the operations of Production Example 14 using 4-(methoxycarbonyl)phenylboronic acid and 2-bromo-5-methoxypyridine, methyl 4-(5-methoxy-2-pyridyl)benzoate was obtained. Hydrolyzing the same with 5N aqueous sodium hydroxide solution, the title compound was obtained as white solid.

Sources & evidence

ORD record
ord-b6e20f7995304c27b8b041e69c372c87
Source dataset
uspto-grants-2009_03
Patent number
US07504412B2

Reaction notes

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