4-Fluorophenylboronic acid → 5-(4-Fluorophenyl)pyridine-2-carboxylic acid

HRID 1784745Notes

Reaction equation

HRID 1784745 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]([C:8]([OH:10])=[O:9])=[N:6][CH:7]=1.[F:11][C:12]1[CH:17]=[CH:16][C:15](B(O)O)=[CH:14][CH:13]=1>>[F:11][C:12]1[CH:17]=[CH:16][C:15]([C:2]2[CH:3]=[CH:4][C:5]([C:8]([OH:10])=[O:9])=[N:6][CH:7]=2)=[CH:14][CH:13]=1

Participants

3

Reactant 2

HCID 2856454-Fluorophenylboronic acidHCID 6085445-Bromopyridine-2-carboxylic acid

Product 1

HCID 231205105-(4-Fluorophenyl)pyridine-2-carboxylic acid

Procedure

Operations similar to those of Production Example 14 were conducted using 5-bromo-2-pyridinecarboxylic acid and 4-fluorophenylboronic acid, to provide the title compound as white solid.

Sources & evidence

ORD record
ord-cb7c899b325548aa861fe8f1f8dc9983
Source dataset
uspto-grants-2009_03
Patent number
US07504412B2

Reaction notes

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