4-Fluorophenylboronic acid → 5-(4-fluorophenyl)pyrimidine-2-carboxylic Acid

HRID 1784748Notes

Reaction equation

HRID 1784748 reaction equation
Br[C:2]1[CH:3]=[N:4][C:5]([C:8]([OH:10])=[O:9])=[N:6][CH:7]=1.[F:11][C:12]1[CH:17]=[CH:16][C:15](B(O)O)=[CH:14][CH:13]=1>>[F:11][C:12]1[CH:17]=[CH:16][C:15]([C:2]2[CH:3]=[N:4][C:5]([C:8]([OH:10])=[O:9])=[N:6][CH:7]=2)=[CH:14][CH:13]=1

Participants

3

Reactant 2

HCID 2856454-Fluorophenylboronic acidHCID 164629705-Bromopyrimidine-2-carboxylic acid

Product 1

HCID 115067865-(4-fluorophenyl)pyrimidine-2-carboxylic Acid

Procedure

Conducting the operations similar to those of Production Example 14 using 5-bromopyrimidine-2-carboxylic acid and 4-fluorophenylboronic acid, the title compound was obtained as white solid.

Sources & evidence

ORD record
ord-b274ef78305f4bec9deccbe1812eac39
Source dataset
uspto-grants-2009_03
Patent number
US07504412B2

Reaction notes

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