4-(5-Chloropyridin-2-yl)benzoic acid → 4-(5-chloropyridin-2-yl)-N-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)benzamide

HRID 1784759Notes

Reaction equation

HRID 1784759 reaction equation
[CH:1]1([C:4]2[N:5]=[C:6]3[CH:11]=[CH:10][C:9]([N+:12]([O-])=O)=[CH:8][N:7]3[C:15]=2[CH3:16])[CH2:3][CH2:2]1.[Cl:17][C:18]1[CH:19]=[CH:20][C:21]([C:24]2[CH:29]=[CH:28][C:27]([C:30](O)=[O:31])=[CH:26][CH:25]=2)=[N:22][CH:23]=1>>[Cl:17][C:18]1[CH:19]=[CH:20][C:21]([C:24]2[CH:29]=[CH:28][C:27]([C:30]([NH:12][C:9]3[CH:10]=[CH:11][C:6]4[N:7]([C:15]([CH3:16])=[C:4]([CH:1]5[CH2:3][CH2:2]5)[N:5]=4)[CH:8]=3)=[O:31])=[CH:26][CH:25]=2)=[N:22][CH:23]=1

Participants

3

Reactant 2

HCID 227304354-(5-Chloropyridin-2-yl)benzoic acidHCID 231205162-Cyclopropyl-3-methyl-6-nitroimidazo[1,2-a]pyridine

Product 1

HCID 452675764-(5-chloropyridin-2-yl)-N-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)benzamide

Procedure

Conducting the operations similar to those of Example 1 using 2-cyclopropyl-3-methyl-6-nitroimidazo[1,2-a]pyridine and 4-(5-chloro-2-pyridyl)benzenecarboxylic acid, the title compound was obtained as white solid.

Sources & evidence

ORD record
ord-ddfe61d417f14693b2cea5cbaec64845
Source dataset
uspto-grants-2009_03
Patent number
US07504412B2

Reaction notes

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