HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen chloride-ethyl acetate → N-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)-5-(4-fluorophenyl)-2-pyridinecarboxamide hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen chloride-ethyl acetate | HCID 21866389 | — |
| Reactant | 5-(4-Fluorophenyl)pyridine-2-carboxylic acid | HCID 23120510 | — |
| Reactant | 2-Cyclopropyl-3-methyl-6-nitroimidazo[1,2-a]pyridine | HCID 23120516 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | N-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)-5-(4-fluorophenyl)-2-pyridinecarboxamide hydrochloride | HCID 23120571 | — |
Reaction Steps
Operations similar to those of Example 1 were conducted using 2-cyclopropyl-3-methyl-6-nitroimidazo[1,2-a]pyridine and 5-(4-fluorophenyl)-2-pyridinecarboxylic acid. The resulting solid was dissolved in ethyl acetate, followed by addition of 4N hydrochloric acid-ethyl acetate solution and concentration under reduced pressure. The title compound was obtained as white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07504412B2 |
| Source dataset | uspto-grants-2009_03 |
| ORD ID | ord-3ac85a5ef6bb47a99958880427975d44 |
| Source note | uspto-grants-2009_03 |