3-(6-(trifluoromethyl)pyridin-3-yl)propanoic Acid → N-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)-3-[6-(trifluoromethyl)-3-pyridyl]propanamide

HRID 1784768Notes

Reaction equation

HRID 1784768 reaction equation
[CH:1]1([C:4]2[N:5]=[C:6]3[CH:11]=[CH:10][C:9]([N+:12]([O-])=O)=[CH:8][N:7]3[C:15]=2[CH3:16])[CH2:3][CH2:2]1.[F:17][C:18]([F:31])([F:30])[C:19]1[N:24]=[CH:23][C:22]([CH2:25][CH2:26][C:27](O)=[O:28])=[CH:21][CH:20]=1>>[CH:1]1([C:4]2[N:5]=[C:6]3[CH:11]=[CH:10][C:9]([NH:12][C:27](=[O:28])[CH2:26][CH2:25][C:22]4[CH:23]=[N:24][C:19]([C:18]([F:17])([F:30])[F:31])=[CH:20][CH:21]=4)=[CH:8][N:7]3[C:15]=2[CH3:16])[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 27833903-(6-(trifluoromethyl)pyridin-3-yl)propanoic AcidHCID 231205162-Cyclopropyl-3-methyl-6-nitroimidazo[1,2-a]pyridine

Product 1

HCID 23120542N-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)-3-[6-(trifluoromethyl)-3-pyridyl]propanamide

Procedure

Conducting the operations similar to those of Example 1 using 2-cyclopropyl-3-methyl-6-nitroimidazo[1,2-a]pyridine and 3-[6-(trifluoromethyl)-3-pyridyl]propionic acid, the title compound was obtained as white solid.

Sources & evidence

ORD record
ord-4d92e00a2dc54f048bb7884db64f9ae2
Source dataset
uspto-grants-2009_03
Patent number
US07504412B2

Reaction notes

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