HuagongsheHuagongshe Chemistry Print Report · For research reference only
4'-(Trifluoromethyl)-[1,1'-biphenyl]-4-carboxylic acid → Ethyl 6-({[4'-(trifluoromethyl) [1,1'-biphenyl]-4-yl]carbonyl}-amino)imidazo[1,2-a]pyridine-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4'-(Trifluoromethyl)-[1,1'-biphenyl]-4-carboxylic acid | HCID 2782719 | — |
| Reactant | Ethyl 6-nitroimidazo(1,2-a)pyridine-2-carboxylate | HCID 12558381 | — |
| Product | Ethyl 6-({[4'-(trifluoromethyl) [1,1'-biphenyl]-4-yl]carbonyl}-amino)imidazo[1,2-a]pyridine-2-carboxylate | HCID 23120543 | 31.1% |
Reaction Steps
Operations similar to Example 1 were conducted using ethyl 6-nitroimidazo[1,2-a]pyridine-2-carboxylate (600 mg) and 4′-(trifluoromethyl)[1,1′-biphenyl]-4-carboxylic acid (700 mg), to provide ethyl 6-({[4′-(trifluoromethyl)[1,1′-biphenyl]-4-yl]carbonyl}-amino)imidazo[1,2-a]pyridine-2-carboxylate (360 mg) as white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07504412B2 |
| Source dataset | uspto-grants-2009_03 |
| ORD ID | ord-7374e82fce514343986cd10121234652 |
| Source note | uspto-grants-2009_03 |