4-(5-Chloropyridin-2-yl)benzoic acid → 4-(5-chloro-2-pyridyl)-N-(2-cyclopropylimidazo[1,2-a]pyridine-6-yl)benzamide

HRID 1784779Notes

Reaction equation

HRID 1784779 reaction equation
[CH:1]1([C:4]2[N:5]=[C:6]3[CH:11]=[CH:10][C:9]([N+:12]([O-])=O)=[CH:8][N:7]3[CH:15]=2)[CH2:3][CH2:2]1.[Cl:16][C:17]1[CH:18]=[CH:19][C:20]([C:23]2[CH:28]=[CH:27][C:26]([C:29](O)=[O:30])=[CH:25][CH:24]=2)=[N:21][CH:22]=1>>[Cl:16][C:17]1[CH:18]=[CH:19][C:20]([C:23]2[CH:28]=[CH:27][C:26]([C:29]([NH:12][C:9]3[CH:10]=[CH:11][C:6]4[N:7]([CH:15]=[C:4]([CH:1]5[CH2:3][CH2:2]5)[N:5]=4)[CH:8]=3)=[O:30])=[CH:25][CH:24]=2)=[N:21][CH:22]=1

Participants

3

Reactant 2

HCID 227304354-(5-Chloropyridin-2-yl)benzoic acidHCID 231205182-Cyclopropyl-6-nitroimidazo[1,2-a]pyridine

Product 1

HCID 690544634-(5-chloro-2-pyridyl)-N-(2-cyclopropylimidazo[1,2-a]pyridine-6-yl)benzamide

Procedure

Operations similar to those of Example 1 were conducted using 2-cyclopropyl-6-nitroimidazo[1,2-a]pyridine and 4-(5-chloro-2-pyridyl)benzenecarboxylic acid, to provide 4-(5-chloro-2-pyridyl)-N-(2-cyclopropylimidazo[1,2-a]pyridine-6-yl)benzamide as white solid. Further treating the resulting compound in the manner similar to Example 36, the title compound was obtained as white solid.

Sources & evidence

ORD record
ord-fac5f2b041624d1c8c5de8b4c0b5b93e
Source dataset
uspto-grants-2009_03
Patent number
US07504412B2

Reaction notes

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