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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1784784Generated: October 30, 2026

Phosphorus oxychloride → 6-Methoxyquinoline

https://huagongshe.com/reaction/1784784

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPhosphorus oxychlorideHCID 24813—
ReactantHCID 21836125HCID 21836125—
SolventAcetonitrileHCID 6342—
Product6-MethoxyquinolineHCID 1486097%

Reaction Steps

3-cyano, 4-oxo, 6-methoxy dihydroquinoline was reacted with phosphorus oxychloride in acetonitrile at 85° C. for 5 hr to give 3-cyano, 4-chloro, 6-methoxy quinoline 97% purity by HPLC

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07504416B2
Source datasetuspto-grants-2009_03
ORD IDord-0e820eadf4754ff9a253078911dc2753
Source noteuspto-grants-2009_03