反应详情

温度

70 °C

A suspension of 2-fluoro-5-methylbenzenesulphonamide (5.3 mmol), obtained according to the process described in Step A of Example 1 starting from 2-fluoro-5-methylaniline, in water (50 mL) is heated at 70° C. and then NaOH 10% w/v is added dropwise until the compound has completely dissolved. Potassium permanganate (3 g) is added in small portions. After stirring for 4 hours, the suspension is discharged by filtration in the hot state and the filtrate is brought to pH 1 by adding 12N HCl. The precipitate obtained is collected by filtration, washed with water and dried to yield the title product in the form of a white solid.

1. customobtained
2. dissolutionhas completely dissolved
3. filtrationthe suspension is discharged by filtration in the hot state
4. additionby adding 12N HCl
5. customThe precipitate obtained
6. filtrationis collected by filtration
7. washwashed with water
8. customdried