3-amino-7,8-dihydro-6H-5-oxa-9-aza-benzocycloheptene-9-carboxylic acid isopropyl ester → 3-[5-Chloro-4-(2-methylcarbamoyl-thiophen-3-ylamino)-pyrimidin-2-ylamino]-7,8-dihydro-6H-5-oxa-9-aza-benzocycloheptene-9-carboxylic acid isopropyl ester
Reaction equation
[CH3:19][NH:20][C:21](=[O:22])[c:23]1[s:24][cH:25][cH:26][c:27]1[NH:28][c:29]1[n:30][c:31]([Cl:36])[n:32][cH:33][c:34]1[Cl:35].[CH:1]([CH3:2])([CH3:3])[O:4][C:5](=[O:6])[N:7]1[CH2:8][CH2:9][CH2:10][O:11][c:12]2[c:13]1[cH:14][cH:15][c:16]([NH2:18])[cH:17]2>>[CH:1]([CH3:2])([CH3:3])[O:4][C:5](=[O:6])[N:7]1[CH2:8][CH2:9][CH2:10][O:11][c:12]2[c:13]1[cH:14][cH:15][c:16]([NH:18][c:31]1[n:30][c:29]([NH:28][c:27]3[c:23]([C:21]([NH:20][CH3:19])=[O:22])[s:24][cH:25][cH:26]3)[c:34]([Cl:35])[cH:33][n:32]1)[cH:17]2Participants
3
Reactant 2
Product 1
Sources & evidence
- ORD record
- ord-05e91391a168415abcb519d18c5178e3
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (6/10)
Reaction notes
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