HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-3-nitropyridine → 3-Nitro-2-vinylpyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-3-nitropyridine | HCID 79613 | — |
| Reactant | Tripropyl-vinyl-stannane | HCID 21909134 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 3-Nitro-2-vinylpyridine | HCID 11829617 | 54% |
Reaction Steps
A mixture of 0.92 g (5.80 mmol) of 2-chloro-3-nitro-pyridine, 1.60 g (5.80 mmol) tripropyl-vinyl-stannane, 0.335 g (0.290 mmol) Pd(PPh3)4 and 10 mL of toluene were combined and refluxed under an inert atmosphere overnight. After routine aqueous workup the crude product was purified by chromatography on silica gel to give 0.470 g (54% yield) of 3-nitro-2-vinyl-pyridine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07504401B2 |
| Source dataset | uspto-grants-2009_03 |
| ORD ID | ord-4582bbaa9e704aacbe4a92fcf7710903 |
| Source note | uspto-grants-2009_03 |