2-Ethylpyridin-3-amine → (3-Bromo-5-triisopropylsilanyloxy-phenyl)-(2-ethyl-pyridin-3-yl)-amine

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Reaction Steps

(3,5-Dibromo-phenoxy)-triisopropyl-silane and 2-ethyl-pyridin-3-ylamine were coupled to give (3-bromo-5-triisopropylsilanyloxy-phenyl)-(2-ethyl-pyridin-3-yl)-amine as described for Example 80. (3-Bromo-5-triisopropylsilanyloxy-phenyl)-(2-ethyl-pyridin-3-yl)-amine was converted to 3-(2-ethyl-pyridin-3-ylamino)-5-(1H-indol-4-yl)-phenol as described in Example 35. 1H NMR (400 MHz, CD3OD): δ 8.02 (d, J=4.8 Hz 1H), 7.66 (dd, J=8.0, 1.5 Hz, 1H), 7.32 (d, J=8.1 Hz, 1H), 7.22 (d, J=3.1 Hz, 1H), 7.14-7.10 (m, 2H), 7.03 (d, J=7.0 Hz, 1H), 6.76 (t, J=1.6 Hz, 1H), 6.69 (s, 1H), 6.61 (d, J=3.3 Hz, 1H), 6.40 (t, J=2.1 Hz, 1H), 2.86 (q, J=7.5 Hz, 2H), 1.25 (t, J=7.5 Hz, 3H).

Provenance & Evidence