Benzyl Bromide → Benzyl 3-benzyloxy-2-nitrobenzoate

Participants

Reaction Steps

3-Hydroxy-2-nitrobenzoic acid (10.5 g) was dissolved in 60 ml of N,N-dimethylformamide, then 15 ml of benzyl bromide and 19.0 g of potassium carbonate were added at 0° C. and the mixture was stirred at room temperature for one night. The reaction solution was filtered through Celite and the filtrate was concentrated in vacuo. Water was added to the resulting residue, the mixture was extracted with ether and the extract was washed with a saturated saline and dried over anhydrous magnesium sulfate. The solvent was evaporated in vacuo to give 20.7 g of benzyl 3-benzyloxy-2-nitrobenzoate.

Provenance & Evidence