Methanol → HCID 67529883, compound

HRID 17849Notes

Reaction equation

HRID 17849 reaction equation
[CH:1]1([NH:4][C:5]2[CH:13]=[CH:12][C:8]([C:9]([OH:11])=[O:10])=[CH:7][C:6]=2[S:14](=[O:17])(=[O:16])[NH2:15])[CH2:3][CH2:2]1.[CH3:18]O>S(=O)(=O)(O)O>[CH:1]1([NH:4][C:5]2[CH:13]=[CH:12][C:8]([C:9]([O:11][CH3:18])=[O:10])=[CH:7][C:6]=2[S:14](=[O:17])(=[O:16])[NH2:15])[CH2:2][CH2:3]1

Participants

4

Reactant 2

HCID 887MethanolHCID 67529499HCID 67529499, compound

Product 1

HCID 67529883HCID 67529883, compound

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Procedure

4-Cyclopropylamino-3-sulphamoylbenzoic acid (3.9 mmol), prepared according to the process described in Step B of Example 1 starting from the compound obtained in the Step above, is then dissolved in sulphuric acid (0.5 mL) and methanol (10 mL), and the mixture is heated at reflux for 4 hours. The solvent is then removed by distillation under reduced pressure and the residue is suspended in water (20 mL). The precipitate obtained is collected by filtration, washed with water and dried to yield the title product in the form of a white solid.

Workup

  1. customobtained in the Step above,
  2. temperatureat reflux for 4 hours
  3. customThe solvent is then removed by distillation under reduced pressure
  4. customThe precipitate obtained
  5. filtrationis collected by filtration
  6. washwashed with water
  7. customdried

Sources & evidence

ORD record
ord-ffacb3a5c9e24272badaa63aeb68e82e
Source dataset
uspto-grants-2010_06
Patent number
US07741320B2

Reaction notes

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