反应详情

4-Cyclopropylamino-3-sulphamoylbenzoic acid (3.9 mmol), prepared according to the process described in Step B of Example 1 starting from the compound obtained in the Step above, is then dissolved in sulphuric acid (0.5 mL) and methanol (10 mL), and the mixture is heated at reflux for 4 hours. The solvent is then removed by distillation under reduced pressure and the residue is suspended in water (20 mL). The precipitate obtained is collected by filtration, washed with water and dried to yield the title product in the form of a white solid.

1. customobtained in the Step above,
2. temperatureat reflux for 4 hours
3. customThe solvent is then removed by distillation under reduced pressure
4. customThe precipitate obtained
5. filtrationis collected by filtration
6. washwashed with water
7. customdried