Triphenylphosphine → HCID 86612602, compound

Participants

Reaction Steps

To diethyl 5-(hydroxymethyl)isophthalate (2.52 gm, 10 mmol) in THF (30 ml), triphenyl phosphine (5.25 gm, 20 mmol) was added followed by thiolacetic acid (1.52 gm, 20 mmol) and Diisopropylazodicarboxylate (4.04 gm, 20 mmol) at 0° C. Reaction mixture was then allowed to come to rt and stirred for 2 h. Then solvent was removed, crude was redissolved in minimum amount of CH2Cl2. With stirring, hexane was added and the resultant solids were discarded. Filtrtae was evaporated to dryness and the residue was column purified to yield diethyl 5-(acetylthiomethyl)isophthalate in 95% yield.

Provenance & Evidence