反应详情

To a solution of 3-amino-3-(3-cyclopropylmethoxy-4-difluoromethoxy-phenyl)-propionic acid methyl ester HCl salt (540 mg 1.5 mmol) in methylene chloride (20 ml) was added water (20 ml) and sodium carbonate (160 mg, 1.5 mmol). The mixture was stirred at room temperature for 30 min then separated in separatory funnel. The organic layer was washed with water (20 ml), brine (20 ml) and dried over magnesium sulfate. The solvent was removed in vacuo. The resulted oil was used in next step without further purification.

1. customthen separated in separatory funnel
2. washThe organic layer was washed with water (20 ml), brine (20 ml)
3. dry with materialdried over magnesium sulfate
4. customThe solvent was removed in vacuo
5. customThe resulted oil was used in next step without further purification