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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1785009Generated: October 31, 2026

4-Fluorophenylboronic acid → benzyl 5-(3,5-dimethylisoxazol4-yl)-4-ethyl-2-formyl-1H-pyrrole-3-carboxylate

https://huagongshe.com/reaction/1785009

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Fluorophenylboronic acidHCID 285645—
Reactant3,5-Dimethylisoxazole-4-boronic acidHCID 2734346—
ReactantBenzyl 4-ethyl-2-formyl-5-iodo-1H-pyrrole-3-carboxylateHCID 11349592—
Productbenzyl 5-(3,5-dimethylisoxazol4-yl)-4-ethyl-2-formyl-1H-pyrrole-3-carboxylateHCID 11302603—

Reaction Steps

Following the procedures described in Example 5, replacing methyl 4-ethyl-2-formyl-5-iodo-1H-pyrrole-3-carboxylate with benzyl 4-ethyl-2-formyl-5-iodo-1H-pyrrole-3-carboxylate and 4-fluorophenylboronic acid with 3,5-dimethylisoxazol-4-ylboronic acid, the title compound was obtained. Proton NMR for the product was consistent with the title compound. HRMS (ES) exact mass calculated for C20H21N2O4 (M+H): 353.1502. Found 353.1496

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07504429B2
Source datasetuspto-grants-2009_03
ORD IDord-a2dc5bd1d16549e89b76f253ffe7b5ef
Source noteuspto-grants-2009_03