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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1785010Generated: October 27, 2026

4-Fluorophenylboronic acid → benzyl 5-(1-benzofuran-2-yl)-4-ethyl-2-formyl-1H-pyrrole-3-carboxylate

https://huagongshe.com/reaction/1785010

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Fluorophenylboronic acidHCID 285645—
ReactantBenzo[b]furan-2-boronic acidHCID 2776266—
ReactantBenzyl 4-ethyl-2-formyl-5-iodo-1H-pyrrole-3-carboxylateHCID 11349592—
Productbenzyl 5-(1-benzofuran-2-yl)-4-ethyl-2-formyl-1H-pyrrole-3-carboxylateHCID 11383195—

Reaction Steps

Following the procedures described in Example 5, replacing methyl 4-ethyl-2-formyl-5-iodo-1H-pyrrole-3-carboxylate with benzyl 4-ethyl-2-formyl-5-iodo-1H-pyrrole-3-carboxylate and 4-fluorophenylboronic acid with 1-benzofuran-2-ylboronic acid, the title compound was obtained. Proton NMR for the product was consistent with the title compound. HRMS (ES) exact mass calculated for C23H20NO4 (M+H): 374.1372. Found 374.1387

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07504429B2
Source datasetuspto-grants-2009_03
ORD IDord-3b32faa020ee47f284ec4b740507d9d3
Source noteuspto-grants-2009_03