3-Nitrophenylboronic Acid → HCID 11337905, compound

HRID 1785011Notes

Reaction equation

HRID 1785011 reaction equation
[CH2:1]([C:3]1[C:4]([C:11]([O:13][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[O:12])=[C:5]([CH:9]=[O:10])[NH:6][C:7]=1I)[CH3:2].FC1C=CC(B(O)O)=CC=1.[N+:31]([C:34]1[CH:35]=[C:36](B(O)O)[CH:37]=[CH:38][CH:39]=1)([O-:33])=[O:32]>>[CH2:1]([C:3]1[C:4]([C:11]([O:13][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[O:12])=[C:5]([CH:9]=[O:10])[NH:6][C:7]=1[C:38]1[CH:37]=[CH:36][CH:35]=[C:34]([N+:31]([O-:33])=[O:32])[CH:39]=1)[CH3:2]

Participants

4

Reactant 3

HCID 16773-Nitrophenylboronic AcidHCID 2856454-Fluorophenylboronic acidHCID 11349592Benzyl 4-ethyl-2-formyl-5-iodo-1H-pyrrole-3-carboxylate

Product 1

HCID 11337905HCID 11337905, compound

Procedure

Following the procedures described in Example 5, replacing methyl 4-ethyl-2-formyl-5-iodo-1H-pyrrole-3-carboxylate with benzyl 4-ethyl-2-formyl-5-iodo-1H-pyrrole-3-carboxylate and 4-fluorophenylboronic acid with 3-nitrophenylboronic acid, the title compound was obtained. Proton NMR for the product was consistent with the title compound. HRMS (ES) exact mass calculated for C21H19N2O5 (M+H): 379.1289. Found 379.1290

Sources & evidence

ORD record
ord-5e99f90fcbcd4a3bb1ebac1e8e78860e
Source dataset
uspto-grants-2009_03
Patent number
US07504429B2

Reaction notes

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