4-Fluorophenylboronic acid → HCID 11221404, compound

HRID 1785012Notes

Reaction equation

HRID 1785012 reaction equation
[CH2:1]([C:3]1[C:4]([C:11]([O:13][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[O:12])=[C:5]([CH:9]=[O:10])[NH:6][C:7]=1I)[CH3:2].FC1C=CC(B(O)O)=CC=1.[CH3:31][C:32]1[O:36][C:35](B(O)O)=[CH:34][CH:33]=1>>[CH2:1]([C:3]1[C:4]([C:11]([O:13][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[O:12])=[C:5]([CH:9]=[O:10])[NH:6][C:7]=1[C:35]1[O:36][C:32]([CH3:31])=[CH:33][CH:34]=1)[CH3:2]

Participants

4

Reactant 3

HCID 2856454-Fluorophenylboronic acidHCID 27343725-Methyl-2-furanboronic AcidHCID 11349592Benzyl 4-ethyl-2-formyl-5-iodo-1H-pyrrole-3-carboxylate

Product 1

HCID 11221404HCID 11221404, compound

Procedure

Following the procedures described in Example 5, replacing methyl 4-ethyl-2-formyl-5-iodo-1H-pyrrole-3-carboxylate with benzyl 4-ethyl-2-formyl-5-iodo-1H-pyrrole-3-carboxylate and 4-fluorophenylboronic acid with 5-methyl-2-furylboronic acid, the title compound was obtained. Proton NMR for the product was consistent with the title compound. HRMS (ES) exact mass calculated for C20H20NO4 (M+H): 338.1382. Found 338.1387

Sources & evidence

ORD record
ord-26361af314ce47278b8becb2705460fe
Source dataset
uspto-grants-2009_03
Patent number
US07504429B2

Reaction notes

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