4-Fluorophenylboronic acid → Benzyl 4-ethyl-2-formyl-5-(5-formyl-2-furyl)-1H-pyrrole-3-carboxylate
Reaction equation
[CH2:1]([C:3]1[C:4]([C:11]([O:13][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[O:12])=[C:5]([CH:9]=[O:10])[NH:6][C:7]=1I)[CH3:2].FC1C=CC(B(O)O)=CC=1.[CH:31]([C:33]1[O:37][C:36](B(O)O)=[CH:35][CH:34]=1)=[O:32]>>[CH2:1]([C:3]1[C:4]([C:11]([O:13][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[O:12])=[C:5]([CH:9]=[O:10])[NH:6][C:7]=1[C:36]1[O:37][C:33]([CH:31]=[O:32])=[CH:34][CH:35]=1)[CH3:2]Participants
4
Procedure
Following the procedures described in Example 5, replacing methyl 4-ethyl-2-formyl-5-iodo-1H-pyrrole-3-carboxylate with benzyl 4-ethyl-2-formyl-5-iodo-1H-pyrrole-3-carboxylate and 4-fluorophenylboronic acid with 5-formyl-2-furylboronic acid, the title compound was obtained. Proton NMR for the product was consistent with the title compound. HRMS (ES) exact mass calculated for C20H18NO5 (M+H): 352.1180. Found 352.1183
Sources & evidence
- ORD record
- ord-cbdd718c05dc4650abd401a673e26b63
- Source dataset
- uspto-grants-2009_03
- Patent number
- US07504429B2
Reaction notes
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