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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1785019Generated: October 30, 2026

4-Fluorophenylboronic acid → Benzyl 5-(2-cyanophenyl)-4-ethyl-2-formyl-1H-pyrrole-3-carboxylate

https://huagongshe.com/reaction/1785019

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Fluorophenylboronic acidHCID 285645—
Reactant2-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)benzonitrileHCID 4198004—
ReactantBenzyl 4-ethyl-2-formyl-5-iodo-1H-pyrrole-3-carboxylateHCID 11349592—
ProductBenzyl 5-(2-cyanophenyl)-4-ethyl-2-formyl-1H-pyrrole-3-carboxylateHCID 11245281—

Reaction Steps

Following the procedures described in Example 5, replacing methyl 4-ethyl-2-formyl-5-iodo-1H-pyrrole-3-carboxylate with benzyl 4-ethyl-2-formyl-5-iodo-1H-pyrrole-3-carboxylate and 4-fluorophenylboronic acid with 2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)benzonitrile, the title compound was obtained. Proton NMR for the product was consistent with the title compound. HRMS (ES) exact mass calculated for C22H19N2O3 (M+H): 359.1390. Found 359.1386

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07504429B2
Source datasetuspto-grants-2009_03
ORD IDord-80261fd924414abf95d179aa81f56f3f
Source noteuspto-grants-2009_03