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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1785023Generated: October 30, 2026

4-Fluorophenylboronic acid → Benzyl 4-ethyl-2-formyl-5-(2-methylphenyl)-1H-pyrrole-3-carboxylate

https://huagongshe.com/reaction/1785023

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Fluorophenylboronic acidHCID 285645—
Reactant2-Methylphenyl boronic acidHCID 2733267—
ReactantBenzyl 4-ethyl-2-formyl-5-iodo-1H-pyrrole-3-carboxylateHCID 11349592—
ProductBenzyl 4-ethyl-2-formyl-5-(2-methylphenyl)-1H-pyrrole-3-carboxylateHCID 11325471—

Reaction Steps

Following the procedures described in Example 5, replacing methyl 4-ethyl-2-formyl-5-iodo-1H-pyrrole-3-carboxylate with benzyl 4-ethyl-2-formyl-5-iodo-1H-pyrrole-3-carboxylate and 4-fluorophenylboronic acid with 2-methylphenylboronic acid, the title compound was obtained. Proton NMR for the product was consistent with the title compound. HRMS (ES) exact mass calculated for C22H22NO3 (M+H): 348.1594. Found 348.1603

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07504429B2
Source datasetuspto-grants-2009_03
ORD IDord-512f2c285af348039890eccf0d469ae4
Source noteuspto-grants-2009_03