4-Fluorophenylboronic acid → HCID 11187753, compound

HRID 1785026Notes

Reaction equation

HRID 1785026 reaction equation
[CH2:1]([C:3]1[C:4]([C:11]([O:13][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[O:12])=[C:5]([CH:9]=[O:10])[NH:6][C:7]=1I)[CH3:2].FC1C=CC(B(O)O)=CC=1.[Cl:31][C:32]1[CH:33]=[C:34](B(O)O)[CH:35]=[CH:36][CH:37]=1>>[Cl:31][C:32]1[CH:37]=[C:36]([C:7]2[NH:6][C:5]([CH:9]=[O:10])=[C:4]([C:11]([O:13][CH2:14][C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)=[O:12])[C:3]=2[CH2:1][CH3:2])[CH:35]=[CH:34][CH:33]=1

Participants

4

Reactant 3

HCID 2856454-Fluorophenylboronic acidHCID 2734323(3-Chlorophenyl)boronic acidHCID 11349592Benzyl 4-ethyl-2-formyl-5-iodo-1H-pyrrole-3-carboxylate

Product 1

HCID 11187753HCID 11187753, compound

Procedure

Following the procedures described in Example 5, replacing methyl 4-ethyl-2-formyl-5-iodo-1H-pyrrole-3-carboxylate with benzyl 4-ethyl-2-formyl-5-iodo-1H-pyrrole-3-carboxylate and 4-fluorophenylboronic acid with 3-chloro phenylboronic acid, the title compound was obtained. Proton NMR for the product was consistent with the title compound. HRMS (ES) exact mass calculated for C21H19ClNO3 (M+H): 368.1048. Found 368.1018

Sources & evidence

ORD record
ord-c9befa699efc4a7dbd35b8be590dfca5
Source dataset
uspto-grants-2009_03
Patent number
US07504429B2

Reaction notes

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