Aminoisobutyric acid → HCID 57594329, compound

HRID 1785043Notes

Reaction equation

[NH2:1][CH2:2][C@@H:3]([NH:21][C:22](=[O:34])[C:23]1[CH:28]=[CH:27][C:26]([O:29][CH:30]([CH3:32])[CH3:31])=[C:25]([Cl:33])[CH:24]=1)[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[N:12]=[C:13]3[C:18]([CH3:19])=[CH:17][CH:16]=[CH:15][N:14]3[CH:20]=2)=[CH:7][CH:6]=1.[CH3:35][C:36]([C:39](O)=[O:40])([CH3:38])[NH2:37]>>[Cl:33][C:25]1[CH:24]=[C:23]([CH:28]=[CH:27][C:26]=1[O:29][CH:30]([CH3:32])[CH3:31])[C:22]([NH:21][C@@H:3]([CH2:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[N:12]=[C:13]3[C:18]([CH3:19])=[CH:17][CH:16]=[CH:15][N:14]3[CH:20]=2)=[CH:7][CH:6]=1)[CH2:2][NH:1][C:39](=[O:40])[C:36]([CH3:38])([CH3:35])[NH2:37])=[O:34]

Participants

Reactant 2

HCID 6119Aminoisobutyric acid

HCID 57594616HCID 57594616, compound

Product 1

HCID 57594329HCID 57594329, compound

Procedure

Following the procedure described above with N-((1S)-2-amino-1-{[4-(8-methylimidazo[1,2-a]pyridin-2-yl)phenyl]methyl}ethyl)-3-chloro-4-[(1-methylethyl)oxy]benzamide and N-[(1,1-dimethylethyl)oxy]carbonyl)-2-methylalanine provided the title product as a white solid. ESMS [M+H]+: 563.2.

Sources & evidence

ORD record: ord-1b38ea44be01460e8865c06d3f979b70
Source dataset: uspto-grants-2009_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07504413B2

Reaction notes

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