HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Hydroxide → Methyl 3-cyano-4-isopropoxybenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Methyl 3-cyano-4-hydroxybenzoate | HCID 11769089 | — |
| Solvent | Water | HCID 962 | — |
| Product | Methyl 3-cyano-4-isopropoxybenzoate | HCID 21956805 | — |
Reaction Steps
To a solution of 3 (0.376 mol) in THF (200 mL) and water (100 mL) was added lithium hydroxide (31.6 g, 0.752 mol) and the mixture stirred for 2 hours. The reaction mixture was filtered through a silica gel plug (the pH of the filtrate was about 7) and concentrated. The residue was dried under vacuum to give 4 (0.376 mol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07504413B2 |
| Source dataset | uspto-grants-2009_03 |
| ORD ID | ord-f29e0524d2bb4f16898678943a66f3e1 |
| Source note | uspto-grants-2009_03 |