HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 7-(Benzyloxy)-4-chloro-6-methoxyquinazoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 7-Benzyloxy-6-methoxy-3H-quinazolin-4-one | HCID 135404718 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 7-(Benzyloxy)-4-chloro-6-methoxyquinazoline | HCID 10661998 | — |
Reaction Steps
After repetition of the reaction so described, a mixture of 7-benzyloxy-6-methoxy-3,4-dihydroquinazolin-4-one (20.3 g), thionyl chloride (440 ml) and DMF (1.75 ml) was heated to reflux for4 hours. The thionyl chloride was evaporated under vacuum and the residue was azeotroped with toluene three times to give 7-benzyloxy-4-chloro-6-methoxyquinazoline.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07504408B2 |
| Source dataset | uspto-grants-2009_03 |
| ORD ID | ord-d9975e79f132408fb3402d78e1cb5a69 |
| Source note | uspto-grants-2009_03 |