HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(4-Azidomethyl-2-methyl-phenyl)-propionic Acid Methyl Ester → 3-(4-Aminomethyl-2-methyl-phenyl)-propionic Acid Methyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(4-Azidomethyl-2-methyl-phenyl)-propionic Acid Methyl Ester | HCID 57431982 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-(4-Aminomethyl-2-methyl-phenyl)-propionic Acid Methyl Ester | HCID 57431980 | 78.5% |
Reaction Steps
A mixture of 3-(4-Azidomethyl-2-methyl-phenyl)-propionic acid methyl ester (0.20 g, 0.86 mmol) and 5% Pd/C (32 mg) in EtOH (50 mL) is exposed to a hydrogen atmosphere (60 psi) at RT overnight. Upon filtering the mixture through Celite, the filtrate is concentrated to yield the title compound (0.14 g, 78%). The material is used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07504433B2 |
| Source dataset | uspto-grants-2009_03 |
| ORD ID | ord-94a6019a1fd24619b8cf383a7ae1c3be |
| Source note | uspto-grants-2009_03 |