Trimethyl borate → HCID 86604775, compound

HRID 1785231Notes

Reaction equation

HRID 1785231 reaction equation
[F:1][C:2]([F:17])([F:16])[C:3]1[CH:8]=[CH:7][C:6]([C:9]2[S:13][C:12]([CH:14]=[O:15])=[CH:11][CH:10]=2)=[CH:5][CH:4]=1.[B:18](OC)([O:21]C)[O:19]C.CC1C=C(C2C=CC(C(F)(F)F)=CC=2)SC=1C=O>>[CH:14]([C:12]1[S:13][C:9]([C:6]2[CH:5]=[CH:4][C:3]([C:2]([F:16])([F:1])[F:17])=[CH:8][CH:7]=2)=[CH:10][C:11]=1[B:18]([OH:21])[OH:19])=[O:15]

Participants

4

Reactant 3

HCID 8470Trimethyl borateHCID 46748195-(4-(Trifluoromethyl)phenyl)thiophene-2-carbaldehydeHCID 219865503-Methyl-5-[4-(trifluoromethyl)phenyl]thiophene-2-carbaldehyde

Product 1

HCID 86604775HCID 86604775, compound

Procedure

The titled compound is prepared from 5-(4-Trifluoromethyl-phenyl)-thiophene-2-carbaldehyde (2.70 g, 10 mmole) and trimethyl borate (5.68 g, 50.0 mmole) in a similar manner to 3-Methyl-5-(4-trifluoromethyl-phenyl)-thiophene-2-carbaldehyde (Preparation 2, Step A).

Sources & evidence

ORD record
ord-7afae79c9f224155b1e94c00ac1c4ebc
Source dataset
uspto-grants-2009_03
Patent number
US07504433B2

Reaction notes

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