HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium sulfate decahydrate → Tert-butyl 4-(hydroxymethyl)piperidine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium sulfate decahydrate | HCID 62649 | — |
| Reactant | 1-Tert-butyl 4-ethyl piperidine-1,4-dicarboxylate | HCID 2758812 | — |
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Tert-butyl 4-(hydroxymethyl)piperidine-1-carboxylate | HCID 2764081 | 95.9% |
Reaction Steps
To a solution of 516 mg of ethyl N-t-butoxycarbonyl-isonipecotate in 30 ml of tetrahydrofuran, 200 mg of lithium-aluminum hydride was added under cooling with ice, followed by 20 minutes' stirring at the same temperature. Sodium sulfate decahydrate was added to the reaction liquid, stirred for 30 minutes and filtered with Celite. Distilling the solvent off under reduced pressure, 414 mg of the title compound was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07504432B2 |
| Source dataset | uspto-grants-2009_03 |
| ORD ID | ord-a324c8fadf9c4d5a9621b3317a7a5cdd |
| Source note | uspto-grants-2009_03 |