tert-Butyl (3R)-3-hydroxypyrrolidine-1-carboxylate → HCID 69766757, compound

HRID 1785286Notes

Reaction equation

HRID 1785286 reaction equation
[F:1][C:2]1([F:19])[CH2:6][CH2:5][C@@H:4]([C@@:7]([OH:18])([C:11]2[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=2)[C:8]([OH:10])=[O:9])[CH2:3]1.O[C@@H:21]1[CH2:25][CH2:24][N:23](C(OC(C)(C)C)=O)[CH2:22]1>>[F:19][C:2]1([F:1])[CH2:6][CH2:5][C@@H:4]([C@@:7]([OH:18])([C:11]2[CH:12]=[CH:13][C:14]([F:17])=[CH:15][CH:16]=2)[C:8]([O:10][C@@H:21]2[CH2:25][CH2:24][NH:23][CH2:22]2)=[O:9])[CH2:3]1

Participants

3

Reactant 2

HCID 6544479tert-Butyl (3R)-3-hydroxypyrrolidine-1-carboxylateHCID 69072808HCID 69072808, compound

Product 1

HCID 69766757HCID 69766757, compound

Procedure

Using (2R)-2-((1R)-3,3-difluorocyclopentyl)-2-hydroxy-2-(4-fluorophenyl)acetic acid and t-butyl (3R)-3-hydroxypyrrolidine-1-carboxylate, the title compound was prepared by a method similar to Steps 2 and 3 of Referential Example 12.

Sources & evidence

ORD record
ord-5cbb865464f746e1989dfb24ba43b7f9
Source dataset
uspto-grants-2009_03
Patent number
US07504432B2

Reaction notes

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