HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2R)-2-[(1R)-3,3-difluorocyclopentyl]-2-hydroxy-2-phenylacetic acid → ((4S)-2-thioxohexahydropyrimidin-4-yl)methyl(2R)-2-((1R)-3,3-difluorocyclopentyl)-2-hydroxy-2-phenylethanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2R)-2-[(1R)-3,3-difluorocyclopentyl]-2-hydroxy-2-phenylacetic acid | HCID 10890505 | — |
| Reactant | (4S)-4-(hydroxymethyl)tetrahydropyrimidine-2(1H)-thione | HCID 55299570 | — |
| Product | ((4S)-2-thioxohexahydropyrimidin-4-yl)methyl(2R)-2-((1R)-3,3-difluorocyclopentyl)-2-hydroxy-2-phenylethanoate | HCID 86597303 | — |
Reaction Steps
Using (2R)-2-((1R)-3,3-difluorocyclopentyl)-2-hydroxy-2-phenylacetic acid and (4S)-4-(hydroxymethyl)tetrahydropyrimidine-2(1H)-thione, the title compound was prepared by a method similar to Step 2 of Referential Example 12.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07504432B2 |
| Source dataset | uspto-grants-2009_03 |
| ORD ID | ord-5888c27d571a46b3b6c9f69781d6646f |
| Source note | uspto-grants-2009_03 |