反应详情

To a solution of 1-(4-nitro-benzyl)-pyrrolidine (1.37 g) in ethanol (66 mL) tin(II)-chloride dihydrate (9.0 g) was added portionwise and the resulting mixture refluxed for 2 h. The reaction mixture was partitioned between ethyl acetate and saturated aqueous sodium bicarbonate solution, the aqueous phase extracted with additional ethyl acetate, the combined organic phases dried (Na2SO4) and evaporated, which gave, after chromatography on silica using dichloromethane/methanol, the title compound (432 mg).

1. temperaturethe resulting mixture refluxed for 2 h
2. customThe reaction mixture was partitioned between ethyl acetate and saturated aqueous sodium bicarbonate solution
3. extractionthe aqueous phase extracted with additional ethyl acetate
4. dry with materialthe combined organic phases dried (Na2SO4)
5. customevaporated
6. customwhich gave