(3-Nitrophenyl)urea → (3-Aminophenyl)urea

HRID 1785308Notes

Reaction equation

HRID 1785308 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([NH:10][C:11]([NH2:13])=[O:12])[CH:7]=[CH:8][CH:9]=1)([O-])=O>[Pd].CO>[NH2:1][C:4]1[CH:5]=[C:6]([NH:10][C:11]([NH2:13])=[O:12])[CH:7]=[CH:8][CH:9]=1

Participants

4

Reactant 1

HCID 3400496(3-Nitrophenyl)urea

Product 1

HCID 108806(3-Aminophenyl)urea

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of N-(3-nitrophenyl)-urea (1.0 g, 5-5 mmol) and methanol (40 mL) was treated with 10% Pd/C (250 mg) and placed under H2 (45 psi) for 2 h. The mixture was then filtered through celite and concentrated to afford N-(3-aminophenyl)-urea (828 mg, 5.5 mmol).

Workup

  1. filtrationThe mixture was then filtered through celite
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-27525ecb4b4a4ca99e802618e7fc8b19
Source dataset
uspto-grants-2009_03
Patent number
US07504410B2

Reaction notes

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