HCID 90816626, compound → HCID 91581604, compound

HRID 1785323Notes

Reaction equation

HRID 1785323 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([NH:8][C:9]2[N:14]=[C:13]([NH:15][CH2:16][CH2:17][CH2:18][NH:19][C:20](=[O:29])[O:21][CH2:22][C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[C:12]([CH2:30][O:31][Si:32]([C:35]([CH3:38])([CH3:37])[CH3:36])([CH3:34])[CH3:33])=[CH:11][N:10]=2)[CH:5]=[CH:6][CH:7]=1>C(#N)C.N>[CH3:36][C:35]([Si:32]([CH3:34])([CH3:33])[O:31][CH2:30][C:12]1[C:13]([NH:15][CH2:16][CH2:17][CH2:18][NH:19][C:20](=[O:29])[O:21][CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)=[N:14][C:9]([NH:8][C:4]2[CH:5]=[CH:6][CH:7]=[C:2]([NH:1][C:20]([NH:19][CH2:18][CH3:17])=[O:21])[CH:3]=2)=[N:10][CH:11]=1)([CH3:38])[CH3:37]

Participants

4

Reactant 1

HCID 90816626HCID 90816626, compound

Product 1

HCID 91581604HCID 91581604, compound

Reagents, catalysts & solvents 2

HCID 222AmmoniaCatalystHCID 6342AcetonitrileSolvent

Procedure

To a solution of phenylmethyl [3-[[2-[(3-aminophenyl)amino]-5-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]pyrimidin-4-yl]amino]propyl]carbamate (225 mg) in acetonitrile (5 ml) ethyl isocyanate (33 μl) was added and the mixture stirred for 18 h at room temperature. Then 5 drops of ammonia solution (25%) were added and the precipitated title compound isolated by filtration (158 mg).

Workup

  1. customthe precipitated title compound
  2. customisolated by filtration (158 mg)

Sources & evidence

ORD record
ord-7173e206bdff49b69b309cc8ba97cc57
Source dataset
uspto-grants-2009_03
Patent number
US07504410B2

Reaction notes

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