反应详情

N2-(4-Amino-phenyl)-5-bromo-N4-prop-2-ynyl-pyrimidine-2,4-diamine (100 mg, 0.3 mmole, prepared in analogy procedure 21) was dissolved in acetonitrile (10 ml) and allyl isothiocyanate (1 ml) was added at room temperature. The reaction mixture was heated under reflux for 3 hours, the solvent removed under reduced pressure and 1-Allyl-3[4-(5-bromo-4-prop-2-ynylamino-pyrimidin-2-ylamino)-phenyl]-thiourea was crystallized from acetone/ethyl acetate/hexanes. Yield 37 mg. ESI-MS: 418.

1. temperatureThe reaction mixture was heated
2. temperatureunder reflux for 3 hours
3. customthe solvent removed under reduced pressure and 1-Allyl-3[4-(5-bromo-4-prop-2-ynylamino-pyrimidin-2-ylamino)-phenyl]-thiourea
4. customwas crystallized from acetone/ethyl acetate/hexanes