Nitronium tetrafluoroborate → HCID 57593186, compound

Participants

Reaction Steps

To a stirring solution of 9-(2-methylsulfanyl-pyrimidin-4-yl)-2-phenyl-6,7,8,9-tetrahydro-pyrimido[1,2-a]pyrimidin-4-one (500 mg, 1.42 mmol) in dichloromethane (10 mL) at 0° C. under nitrogen was added nitronium tetrafluoroborate in a 0.5M solution (7 mL, 3.55 mmol). External cooling removed and reaction warmed to room temperature while stirring for 1 h. Reaction washed with 5% sodium bicarbonate and saturated ammonium chloride. Organic concentrated under vacuum and orange solid isolated after purification on silica. M+1=397.

Provenance & Evidence