HCID 57593146, compound → HCID 57593155, compound

Participants

Reaction Steps

A suspension of 3-nitro-9-(2-phenethylamino-pyrimidin -4-yl)-2-phenyl -6,7,8,9tetrahydro-pyrimido[1,2-a]pyrimidin-4-one (40 mg, 0.09 mmol) in methanol (10 mL) was stirred with 10 % palladium on carbon (5 mg) under an atmosphere of hydrogen for 4 h. Reaction mixture filtered through a bed of Celite, and final product isolated as a white solid after removal of solvent under vacuum. M+1=440 1NMR (CDCl3) t (2H, 2.20 ppm), t (2H, 2.91 ppm), dd (2H, 3.67 ppm), s (2H, 4.07 ppm), m (4H, 4.15 ppm), s (1H, 5.10 ppm), d (1H, 7.17 ppm), m (3H, 7.24 ppm), m (2H, 7.31 ppm), m (1H, 7.36 ppm), t (2H, 7.46 ppm), d (2H, 7.79 ppm), d (1H, 8.03 ppm).

Provenance & Evidence