Dichloromethane → HCID 57593142, compound

HRID 1785438Notes

Reaction equation

HRID 1785438 reaction equation
C(OC(=O)[NH:10][CH2:11][CH2:12][CH:13]1[CH2:18][N:17]2[C:19](=[O:29])[CH:20]=[C:21]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[N:22]=[C:16]2[N:15]([C:30]2[CH:35]=[CH:34][N:33]=[C:32]([NH:36][CH2:37][CH2:38][C:39]3[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=3)[N:31]=2)[CH2:14]1)C1C=CC=CC=1.ClCCl.[H][H]>[Pd].CO>[NH2:10][CH2:11][CH2:12][CH:13]1[CH2:18][N:17]2[C:19](=[O:29])[CH:20]=[C:21]([C:23]3[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=3)[N:22]=[C:16]2[N:15]([C:30]2[CH:35]=[CH:34][N:33]=[C:32]([NH:36][CH2:37][CH2:38][C:39]3[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=3)[N:31]=2)[CH2:14]1

Participants

6

Reactant 3

HCID 6344DichloromethaneHCID 11204190HCID 11204190, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 57593142HCID 57593142, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of {2-[6-Oxo-1-(2-phenethylamino-pyrimidin-4-yl)-8-phenyl-1,3,4,6-tetrahydro-2H-pyrimido[1,2-a]pyrimidin-3-yl]-ethyl}-carbamic acid benzyl ester (100 mg, 0.17 mmol), dichloromethane (5 mL) and methanol (15 mL) was added 10% palladium on carbon (5 mg) and stirred at room temperature over an atmosphere of hydrogen overnight. Reaction filtered through a bed of Celite, and solvent removed under vacuum to afford a white solid. M+1=468.

Workup

  1. customReaction
  2. filtrationfiltered through a bed of Celite, and solvent
  3. customremoved under vacuum
  4. customto afford a white solid

Sources & evidence

ORD record
ord-d242b8ffa3834548bc2828bbe0993657
Source dataset
uspto-grants-2009_03
Patent number
US07504403B2

Reaction notes

Loading…