反应详情

The mixture of N-[1-(3-bromo-phenyl)-1-methyl-ethyl]-2-chloro-acetamide (1.0 g, 3.5 mmol), thiourea (0.32 g, 4.2 mmol), acetic acid (1.5 mL) in ethanol (7 mL) was heated to reflux for 10 h and brought to room temperature. Water was added to the mixture until a precipitate was formed which was filtered. The filtrate was made basic pH 7-8 with 15% NaOH. The product was extracted with ethyl acetate and concentrated to afford a yellow solid. M+1=214.

1. temperaturewas heated
2. temperatureto reflux for 10 h
3. custombrought to room temperature
4. customwas formed which
5. filtrationwas filtered
6. extractionThe product was extracted with ethyl acetate
7. concentrationconcentrated
8. customto afford a yellow solid