反应详情

温度

160 °C

4-Cyano-3-phenyl-but-3-enoic acid ethyl ester (crude, 9.37 g, 0.043 mol), ethylenediamine (3 mL, 0.043 mol) were mixed in dichlorobenze (20 mL) and heated at 160° C. overnight. The resulting suspension was cooled to room temperature, filtered, and the filtrated cake was washed with EtOAc and finally dried to provide the title compound as a brownish yellow solid. MS m/e 213 (M+H)+.

1. temperatureThe resulting suspension was cooled to room temperature
2. filtrationfiltered
3. washthe filtrated cake was washed with EtOAc
4. customfinally dried