HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,4-Dichloropyrimidine → 1-(6-Chloro-pyrazin-2-yl)-7-phenyl-2,3-dihydro-1H-imidazo[1,2-a]pyridin-5-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,4-Dichloropyrimidine | HCID 77531 | — |
| Reactant | Imidazo(1,2-a)pyridin-5(1H)-one, 2,3-dihydro-7-phenyl- | HCID 3050276 | — |
| Reactant | 1-(2-Methylsulfanyl-pyrimidin-4-yl)-7-phenyl-2,3-dihydro-1H-imidazo[1,2-a]pyridin-5-one | HCID 57593160 | — |
| Product | 1-(6-Chloro-pyrazin-2-yl)-7-phenyl-2,3-dihydro-1H-imidazo[1,2-a]pyridin-5-one | HCID 57593194 | — |
Reaction Steps
Following the procedure described in the synthesis of 1-(2-methylsulfanyl-pyrimidin -4-yl)-7-phenyl-2,3-dihydro-1H-imidazo[1,2-a]pyridin-5-one, but using 2,6-dichloropyrimidine as the coupling component, 7-phenyl-2,3-dihydro-1H-imidazo[1,2-a]pyridin-5-one (0.5 g, 2.4 mmol) was converted into the title product as a pale yellow solid. MS m/e 325 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07504403B2 |
| Source dataset | uspto-grants-2009_03 |
| ORD ID | ord-b0cd299ad92a4b7097196a47ab40341a |
| Source note | uspto-grants-2009_03 |