2-(2-Chlorophenyl)ethylamine → 1-{6-[2-(2-Chloro-phenyl)-ethylamino]-pyrimidin-4-yl}-8-phenyl-1,2,3,4-tetrahydro-pyrido[1,2-a]pyrimidin-6-one

HRID 1785472Notes

Reaction equation

HRID 1785472 reaction equation
C(N[C:10]1[N:15]=[C:14]([N:16]2[CH2:21][CH2:20][CH2:19][N:18]3[C:22](=[O:32])[CH:23]=[C:24]([C:26]4[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=4)[CH:25]=[C:17]23)[CH:13]=[CH:12][N:11]=1)CC1C=CC=CC=1.ClC1N=CN=C(N2CCCN3C(=O)C=C(C4C=CC=CC=4)C=C23)C=1.[Cl:57][C:58]1[CH:63]=[CH:62][CH:61]=[CH:60][C:59]=1[CH2:64][CH2:65][NH2:66]>>[Cl:57][C:58]1[CH:63]=[CH:62][CH:61]=[CH:60][C:59]=1[CH2:64][CH2:65][NH:66][C:12]1[N:11]=[CH:10][N:15]=[C:14]([N:16]2[CH2:21][CH2:20][CH2:19][N:18]3[C:22](=[O:32])[CH:23]=[C:24]([C:26]4[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=4)[CH:25]=[C:17]23)[CH:13]=1

Participants

4

Reactant 3

HCID 831172-(2-Chlorophenyl)ethylamineHCID 112123971-(2-Phenethylamino-pyrimidin-4-yl)-8-phenyl-1,2,3,4-tetrahydro-pyrido[1,2-a]pyrimidin-6-oneHCID 575931531-(6-Chloro-pyrimidin-4-yl)-8-phenyl-1,2,3,4-tetrahydro-pyrido[1,2-a]pyrimidin-6-one

Product 1

HCID 114424971-{6-[2-(2-Chloro-phenyl)-ethylamino]-pyrimidin-4-yl}-8-phenyl-1,2,3,4-tetrahydro-pyrido[1,2-a]pyrimidin-6-one

Procedure

Followed the same procedure described for the synthesis of 1-(2-phenethylamino-pyrimidin-4-yl)-8-phenyl-1,2,3,4-tetrahydro -pyrido[1,2-a]pyrimidin-6-one, 1-(6-chloro-pyrimidin-4-yl)-8-phenyl-1,2,3,4-tetrahydro -pyrido[1,2-a]pyrimidin-6-one (0.136 g, 0.40 mmol) was reacted with 2-(2-chlorophenyl)ethylamine (0.17 mL, 1.2 mmol) to give the title compound as a yellow solid. MS m/e 458 (M+H)+.

Sources & evidence

ORD record
ord-cb6bf0074c9b43fd9e0c98dcafb44ec9
Source dataset
uspto-grants-2009_03
Patent number
US07504403B2

Reaction notes

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