1-(2-Phenethylamino-pyrimidin-4-yl)-8-phenyl-1,2,3,4-tetrahydro-pyrido[1,2-a]pyrimidin-6-one → HCID 11751382, 화합물

HRID 1785473노트

반응식

HRID 1785473 반응식
C(N[C:10]1[N:15]=[C:14]([N:16]2[CH2:21]C[CH2:19][N:18]3[C:22](=[O:32])[CH:23]=[C:24]([C:26]4[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=4)[CH:25]=[C:17]23)[CH:13]=[CH:12][N:11]=1)CC1C=CC=CC=1.[NH2:33][CH:34]([CH3:44])[CH2:35][C:36]1[CH:37]=[C:38]([CH2:42][OH:43])[CH:39]=[CH:40][CH:41]=1>>[OH:43][CH2:42][C:38]1[CH:37]=[C:36]([CH2:35][CH:34]([NH:33][C:10]2[N:15]=[C:14]([N:16]3[C:17]4=[CH:25][C:24]([C:26]5[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=5)=[CH:23][C:22](=[O:32])[N:18]4[CH2:19][CH2:21]3)[CH:13]=[CH:12][N:11]=2)[CH3:44])[CH:41]=[CH:40][CH:39]=1

참가 물질

3

반응물 2

HCID 112123971-(2-Phenethylamino-pyrimidin-4-yl)-8-phenyl-1,2,3,4-tetrahydro-pyrido[1,2-a]pyrimidin-6-oneHCID 24721512HCID 24721512, 화합물

생성물 1

HCID 11751382HCID 11751382, 화합물

실험 절차

Following the same procedure described for the synthesis of 1-(2-phenethylamino-pyrimidin-4-yl)-8-phenyl-1,2,3,4-tetrahydro-pyrido[1,2-a]pyrimidin-6-one, the sulfoxide/sulfone (0.4 g) was displaced with [3-(2-amino-propyl)-phenyl]-methanol (1.2 eq) to give the title compound as a light yellow solid. MS m/e 454 (M+H)+.

출처 및 근거

ORD 기록
ord-34f352eead4448779d7bf3a6aa2543d9
출처 데이터셋
uspto-grants-2009_03
특허 번호
US07504403B2

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